Minimal Stimulation and Natural Cycle In Vitro Fertilization by Gautam N. Allahbadia & Markus Nitzschke

Author:Gautam N. Allahbadia & Markus Nitzschke
Language: eng
Format: epub
Publisher: Springer India, New Delhi

Conclusion

Our experience shows that ovulation can successfully be controlled by the use of Clomiphene citrate, as described by Teramoto (Teramoto and Kato 2007) and does not necessarily require GnRH analogs for pituitary suppression. This knowledge opens a new space for development of alternative protocols respecting the patients’ own physiology with no need for heavy stimulation. Patients with ovarian insufficiency may benefit from this approach, which can be offered before referring them to egg donation. In order to achieve high pregnancy rates in patients with low ovarian reserves, it is important to evaluate the patient’s cycle pattern or to diagnose a possible cycle disorder. Then, the treatment can be individually fixed depending on the age of the patient, her ovarian reserve, and her cycle pattern. Using this empiric approach, we defined four different stages of ovarian insufficiency with the related cycle disorders. We believe that this classification may become a helpful tool for clinicians to evaluate the ovarian reserve of their patients clinically, hoping that this new approach will open a new field of investigation.

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